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Publications

Research and publishing are vital to Reddy Lab's mission to advance understanding of age-related diseases. By studying Healthy Aging, Dementia, and neurodegenerative diseases, we provide insights that foster innovation in treatment and prevention. Sharing our findings not only spreads knowledge within the scientific community but also encourages collaboration and new ideas. Additionally, our research raises awareness about chronic conditions like Diabetes, Obesity, and Cardiovascular diseases, which relate to cognitive decline. Through our dedication to research and publication, Reddy Lab aims to improve health outcomes for those affected by these issues.

New Research by Dr. Sudhir Kshirsagar: Unveiling the Therapeutic Potential of Mitophagy Enhancers in Alzheimer's Disease

April 2nd,  2025

  • Recent research led by Dr. Sudhir Kshirsagar highlights the therapeutic potential of DDQ, a small molecule, in addressing the challenges posed by late-onset Alzheimer's disease (AD). The study demonstrates that DDQ not only improves cognitive performance in humanized Abeta knockin mice but also enhances mitochondrial function and reduces neuroinflammation. Key findings reveal that DDQ promotes mitochondrial biogenesis and mitophagy, suggesting its promise as a neuroprotective agent for combating AD and other neurodegenerative disorders. Check out the full article for an in-depth look at these groundbreaking results!

        https://pubmed.ncbi.nlm.nih.gov/40158867/


  • Another recent research from Dr. Sudhir Kshirsagar explores the beneficial effects of mitophagy enhancers on mitochondrial and synaptic toxicities induced by amyloid beta in Alzheimer's disease. This study highlights how mitophagy enhancers—specifically Urolithin A, actinonin, tomatidine, and nicotinamide riboside—can reverse mitochondrial dysfunction and synaptic damage in mutant APP-expressing mouse hippocampal neurons. The results reveal significant improvements in mitochondrial structure and function, emphasizing the potential of these enhancers, especially Urolithin A, as therapeutic candidates for combating the challenges of Alzheimer's disease. Check out the full article for more details!

        https://pubmed.ncbi.nlm.nih.gov/40157622/

How to manage sleep problems in dementia?

March 17th, 2025

Sleep disturbances are a significant concern for individuals living with dementia, adversely affecting their overall health and quality of life, as well as that of their family members and caregivers. Dementia, a progressive neurodegenerative condition characterized by cognitive decline, often coexists with various comorbidities, including cardiovascular disease, diabetes, obesity, anxiety, depression, and thyroid disorders, which can exacerbate cognitive impairment and complicate its management. This section highlights the complex relationship between dementia and these comorbidities, focusing on the prevalence and impact of sleep problems, which are common among dementia patients and can accelerate cognitive decline while increasing the burden on caregivers. By reviewing recent research, we underscore the importance of identifying and managing modifiable risk factors for sleep disturbances and advocating for integrated treatment strategies that address both cognitive challenges and sleep-related issues. Furthermore, we emphasize the need for additional research to develop effective interventions for managing sleep disturbances in dementia, ultimately improving the quality of life for both patients and caregivers. Understanding the connections between dementia, comorbidities, and sleep issues is crucial for establishing comprehensive care strategies, and this content aims to inform healthcare professionals about current knowledge while promoting the implementation of evidence-based practices in dementia care.

Read article here

Latest Publications

This section contains important articles about our work at Reddy Lab

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching.

Amyloid-β and phosphorylated tau are the key biomarkers and predictors of Alzheimer’s disease.

Reddy H, Kshirsagar S, Islam MA, Baig J, Pradeepkiran JA.

https://pubmed.ncbi.nlm.nih.gov/38739937/  

Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars.

Kshirsagar S, Islam MA, Reddy AP, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/40034533/

The impact of sleep and exercise on brain atrophy in mild cognitive impairment.

Mian M, Tahiri J, Habbal S, Aftan F, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/39732176/

Drug Discovery Articles

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching.

Pradeepkiran JA, Rawat P, Reddy AP, Orlov E, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/38902281/


DDQ anti-aging properties expressed with improved mitophagy in mutant tau HT22 neuronal cells.

Pradeepkiran JA, Rawat P, Reddy AP, Orlov E, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/38244850/


Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer's disease.

Vijayan M, Bose C, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/33839321/


Protective effects of a small-molecule inhibitor DDQ against tau-induced toxicities in a transgenic tau mouse model of Alzheimer's disease.

Vijayan M, George M, Bunquin LE, Bose C, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/34559191/


Anti-brain Aging Effects of Small Molecule Inhibitor DDQ.

Vijayan M, Bose C, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/33768469/


Small molecules as therapeutic drugs for Alzheimer's disease.

Oliver DMA, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/30877034/

Biomarker Development Articles

MicroRNA-455-3P as a peripheral biomarker and therapeutic target for mild cognitive impairment and Alzheimer's disease.

Islam MA, Sultana OF, Bandari M, Kshirsagar S, Manna PR, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/39153602/


MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease.

Kumar S, Morton H, Sawant N, Orlov E, Bunquin LE, Pradeepkiran JA, Alvir R, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/34781166/


Novel MicroRNA-455-3p and its protective effects against abnormal APP processing and amyloid beta toxicity in Alzheimer's disease.

Kumar S, Reddy AP, Yin X, Reddy PH.

 https://pubmed.ncbi.nlm.nih.gov/31181293/


MicroRNA-455-3p as a Potential Biomarker for Alzheimer's Disease: An Update.

Kumar S, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/29527164/


MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer's disease.

Kumar S, Vijayan M, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/28934394/


A New Discovery of MicroRNA-455-3p in Alzheimer's Disease.

Kumar S, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/31524168/

Drug Discovery Molecular Basis of Alzheimer’s Disease Articles

Reduced VDAC1, Maintained Mitochondrial Dynamics and Enhanced Mitochondrial Biogenesis in a Transgenic Tau Mouse Model of Alzheimer's Disease.

Vijayan M, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/35955694/


A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model.

Vijayan M, Alvir RV, Alvir RV, Bunquin LE, Pradeepkiran JA, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/35801276/


Reduced VDAC1 protects against Alzheimer's disease, mitochondria, and synaptic deficiencies.

Manczak M, Sheiko T, Craigen WJ, Reddy PH. https://pubmed.ncbi.nlm.nih.gov/23948905/


Is the mitochondrial outer membrane protein VDAC1 therapeutic target for Alzheimer's disease?

Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/22995655/


Rlip76 in ageing and Alzheimer's disease: Focus on oxidative stress and mitochondrial mechanisms.

Bandaru M, Sultana OF, Islam MA, Rainier A, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/39617058/


The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients.

Bose C, Kshirsagar S, Vijayan M, Kumar S, Singh SP, Hindle A, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/37926360/


Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupts Rlip function in Alzheimer's disease.

Baig J, Sawant N, Rawat P, Reddy AP, Reddy PH, Kshirsagar S.

https://pubmed.ncbi.nlm.nih.gov/37633469/


Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer's Disease?

Hindle A, Singh SP, Pradeepkiran JA, Bose C, Vijayan M, Kshirsagar S, Sawant NA, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/35682775/





Human Healthy Aging Studies

Healthy brain aging and delayed dementia in Texas rural elderly.

Basu T, Sehar U, Malhotra K, Culberson J, Khan H, Morton H, Orlov E, Brownell M, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/37652312/


Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas.

Brownell M, Sehar U, Kshirsagar S, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/38549637/


Effects of Sleep Deprivation on Brain Atrophy in Individuals with Mild Cognitive Impairment and Alzheimer's Disease.

Sehar U, Mukherjee U, Khan H, Brownell M, Malhotra K, Culberson J, Alvir RV, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/38942198/


Comprehensive understanding of Hispanic caregivers: Focus on innovative methods and validations.

Sehar U, Rawat P, Choudhury M, Boles A, Culberson J, Khan H, Malhotra K, Basu T, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/37313490/


Caregivers with cancer patients: focus on Hispanics.

Bisht J, Rawat P, Sehar U, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/36765585/


Support provided by caregivers for community-dwelling diabetic Hispanic adults with intellectual disabilities and comorbid conditions.

Rawat P, Sehar U, Bisht J, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/36835260/


Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer’s disease in elderly. 

Mukherjee U, Sehar U, Brownell M, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/39154978/


Sleep deprivation in dementia comorbidities: Focus on cardiovascular disease, diabetes, anxiety/depression and thyroid disorders. 

Mukherjee U, Sehar U, Brownell M, Reddy PH.

https://pubmed.ncbi.nlm.nih.gov/39571101/

For a complete list of Reddy Lab publications, please click here.

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